B-Circadin™

The circadian rhythm resynchronizer

Edition Date :
August 11, 2018

In 2017, the Nobel Prize in Physiology or Medicine awarded discoveries on the molecular mechanisms controlling circadian rhythm. This global rhythm is regulated by the brain, but the skin, specifically each cell, possesses its own internal clock governing major biological responses following this 24-hour rhythm. Four genes are implicated in circadian rhythm: B-mal, Per, Cry and Clock. But their expression can be altered by external factors such as stress, jet lag, or exposure to blue light. A dysregulated circadian rhythm affects the skin well-being, that shows signs of fatigue.

B-Circadin has demonstrated its efficacy to resynchronize the rhythm of Bmal-1, Per and Cry circadian genes on a unique model of synchronized skin exposed to blue light as a stress factor to deregulate its circadian rhythm. As a consequence, it also demonstrated its efficiency in regulating key biological functions such as aquaporin 3 and Nrf2 pathway, known to follow a circadian rhythm. Thanks to B-Circadin, the skin well-being is restored. B-Circadin also showed a protective action against blue light induced oxidative stress on skin cells.

It is extracted from Lespedeza capitata, a medicinal plant originated from South Korea. 

To discover our other active ingredients, visit our homepage Clariant Active Ingredients.

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Alexandre Lapeyre

Alexandre Lapeyre

Global Technical Marketing Manager

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  • Benefits

    • Old medicinal plant: Lespedeza capitata

    • Counters the negative effects of blue light

    • Resynchronizes skin cells circadian rhythm

    • Powerful anti-fatigue effect (puffiness, dark circles)

    • Improves skin complexion

  • MSDS and TDS

  • Applications

    B-Circadin is an active ingredient that can be used in a large variety of skincare and cosmetic products, such as:

    • Skin rhythm protection care

    • Anti-blue light skin care products

    • Brightening products

    • Anti-fatigue treatments

  • Technical Data

    INCI Name: Propanediol, Water, Lespedeza Capitata Leaf/Stem Extract

    Use level: 1-5%

    Appearance: yellow liquid

  • Associations

    B-Circadin can be associated in formulations with Fuligo and MultiEx BSASM for a large anti-fatigue effect.
  • Augmented Reality

    The Clariant Active Ingredients App guides you through the world of Clariant Active Ingredients revolutionary skin care product B-Circadin in Augmented Reality. Indulge into this interactive experience and discover how our daily lifestyle affects our skin circadian rhythm. Together with our new Clariant member Clark you will explore an intuitive journey about skin circadian rhythm, cells processes and our newest innovation B-Circadin.

    Download Link Apple App Store: https://itunes.apple.com/de/app/active-ingredient/id1363984621?l=en&mt=8

    Download Link Google App Store: https://play.google.com/store/apps/details?id=com.framefield.aractiveingredient

    You find the Marker to start the Augmented Reality Application under the chapter DOWNLOADS as PDF file - please print the PDF. By pointing your device at the marker you can experience this Augmented Reality and share with friends, family and colleagues.


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This information corresponds to the present state of our knowledge and is intended as a general description of our products and their possible applications. Clariant makes no warranties, express or implied, as to the information’s accuracy, adequacy, sufficiency or freedom from defect and assumes no liability in connection with any use of this information. Any user of this product is responsible for determining the suitability of Clariant’s products for its particular application.<br />
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