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Health Care Excipients
Solubilizers for Standard Applications

About 40% of new chemical entities invented as potential disease relevant APIs are poorly water soluble and cannot be absorbed effectively in the gastrointestinal tract due to their complex chemical structures or absorption profiles resulting into their failure. This increases the burden on pharmaceutical companies not only in financial aspect but also, they lose their competitive advantage and speed to the market. The poor bioavailability of APIs is not only responsible for reduced drug efficacy but also may cause undesirable side effects upon administration.

How can Clariant help you to get a solution? We offer a wide range of solubilizers that will increase the API performance

  • PEGs
  • PEG-Derivatives

The pharmaceutical formulators can increase the bioavailability of the Active Pharmaceutical ingredient (API) by using solubility enhancement excipients with the benefit of speeding the time to market

Related products

  • VitiPure HCO 40

    VitiPure HCO 40 is versatile non-ionic solubilizer and emulsifier enhancing the solubility and bioavailability of hydrophobic APIs and fat-soluble vitamins. VitiPure HCO 40 is obtained by reacting 40 moles of ethylene oxide with 1 mole of hydrogenated castor oil. At the room temperature it appears as white to yellowish paste. VitiPure HCO 40 is suitable for SEDDS and SMEDDS. It is typically used into formulations such as Topicals (Cream, Hot processing), Solid orals (Hot melt extrusion, Spray drying, Hard shell capsules, Soft shell capsules, Tablets, Instant & modified release), Liquid preparations (Solution).

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  • VitiPure CO 35

    VitiPure CO 35 is a non-ionic solubiliser and emulsifying agent for the human and veterinary pharmaceutical industries. It is made by reacting castor oil with ethylene oxide in a molar ratio of 1:35. At room temperature it appears as pale-yellow oily liquid. It forms clear solutions in water. It is typically used into formulations such as Topicals (Cream, Hot processing), Solid orals (Hot melt extrusion, Spray drying, Hard shell capsules, Soft shell capsules, Tablets, Instant release), Liquid preparations (Solution).

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  • VitiPure L 20

    VitiPure L 20 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer. It is an oily, yellow or brownish-yellow, clear or slightly opalescent liquid with a faint odor. VitiPure L 20 can be used in various pharmaceutical formulations. It is typically used into formulations such as Topicals (Cold processing, Hot processing, Cream, Emulsion, Foam, Gel), Solid orals (Hot melt extrusion, Spray drying, Hard shell capsules, Soft shell capsules, Tablets, Instant release), Liquid preparations (Solution, Suspension) and Suppositories.Generic name: Polysorbate 20

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  • VitiPure O 80

    VitiPure O 80 is a non-ionic, hydrophilic emulsifier, co-emulsifier, solubilizer and suspension stabilizer used widely in various biopharmaceutical formulations. It appears as amber liquid in room temperature with a faint characteristic odor. VitiPure O 80 has a broad working pH range and offers good skin tolerance. It is typically used into formulations such as Topicals (Cold processing, Hot processing, Cream, Emulsion, Foam, Gel, Hydrophilic ointment, Lipophilic ointment), Solid orals (Hot melt extrusion, Spray drying, Conventional pellets, Hard shell capsules, Multiple-unit tablets, Single-unit tablets, Soft shell capsules, Tablets, Enteric release, Instant release, Aqueous Coating), Liquid preparations (Solution, Suspension) and Suppositories.Generic name: Polysorbate 80

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  • VitiPure P 188

    VitiPure P 188 is all rounder non-ionic polymer suitable for various pharmaceutical applications. It is supplied as a white to slightly yellowish flakes/powder with a waxy consistency. It is freely soluble in ethanol and water (opalescent solution). It is used as a wetting agent, emulsifier, solubilizer and bioavailability enhancer of poorly soluble APIs. It is typically used into formulations such as Topicals (Cream, Hot processing, Cold processing, Foam, Gel), Solid orals (Hot melt extrusion, Spray drying, Hard shell capsules, Instant release, extended release, matrix-type system, Reservoir-type system, Film), Liquid preparations (Solution). Generic name: Poloxamer 188 (Ph. Eur., USP/NF)

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