Protection from Moisture
Protecting healthcare products from moisture
Moisture is most often an enemy of pharmaceutical and healthcare products, as it can affect:
- Physical stability –
- - drug appearance (i.e. color)
- - dissolution characteristics
- - accuracy of delivery
- - mechanical properties
- Chemical stability –
- - loss of potency
- - degradation products
Hydrolysis occurs when there is a reaction with a molecule that results in the cleavage of a chemical bond within the molecule. Many drug forms and functional groups, particularly esters and amides, have a high level of reactivity to moisture, which can impact the drug’s chemical stability, physical stability, and metabolism.
Disintegrants and/or excipients are commonly used in pharmaceutical products to facilitate solubility and bioavailability. They affect dissolution rates and absorption or provide additional therapeutic or delivery-system benefit. Consequently, these ingredients can also affect drug stability due to their interaction with moisture.
Nutritional supplements, vitamins, minerals and other nutraceuticals are also prone to physical and chemical instability due to moisture. Like in pharmaceuticals, crystalline materials can deliquesce, and water-soluble solids can begin to dissolve.
Moisture can also have a significant impact on diagnostic reagents, whether in pregnancy tests, rapid tests, or molecular diagnostics, altering their stability and their ability to provide accurate results.
By controlling the relative humidity (RH) inside the package or delivery system, water content and water activity (aW) can be stabilized and chemical hydrolysis reduced, preserving healthcare products within stability parameters throughout shelf life.
For more information about oxygen and moisture protection solutions, visit our Healthcare packaging page.
Please contact us for safety and regulatory details or the Material Safety Data Sheet (MSDS).