Anti-aging ingredients

Rootness™ Energize: recharges cells' batteries for improved biological functions

For biological functions to take place, cells need energy molecules, called ATP. With age, ATP levels decrease and these biological functions, such as protein production, are less efficient. For skin, this results in a decay of the overall structures and to a loss of elasticity and firmness.

To reactivates the overall metabolism processes to increase energy production by skin cells, Clariant Active Ingredients developed Rootness Energize. Its power boost relaunches skin matrix compounds synthesis and maturation, such as collagen and elastic fibers. As a consequence, the main drawbacks of energy-deprived skin are strongly improved, from skin elasticity to tonicity and firmness.

 

 

 

 

   

Prenylium®: protects the matrisome to reinforce the extracellular matrix

The matrisome is the set of genes that code for elements contributing to extracellular matrix integrity and skin physiology. With the passing years, the activity of these genes decrease and the level of key constituent of the ECM decrease, leading to wrinkles apparition.

Prenylium modulates expression of CCN-1, a protein that controls the balance between production and degradation of collagen. In addition, it stimulates expressions of COL3A1 and DCN, genes encoding for collagen III and decorin, major components of the extracellular matrix. By protecting the matrisome, Prenylium roots the skin in youth.

 

 

 

   

Epseama®: targeting epigenetics through the non long-coding RNA nc886

Gene expression and how they are translated into proteins can be influenced by external factors. This phenomenon is called epigenetics. Some genes are transcripted in non coding RNA (ncRNA), that will not be translated into proteins. Their function is to regulate information flow from DNA to proteins. Recently, it has been shown that the expression of a long non-coding RNA called nc866 decrease with age and can affect skin rejuvenation. 

Clariant Active Ingredient is the first company to have developed an active ingredient for skincare that targets the long-coding RNA nc886, to fight chronoaging and photoaging. Called Epseama, it is made of an extract of Laminaria japonica, a seaweed cultivated in South Korea and commonly used in asian food due to its valuable composition.

Thanks to Epseama, difficult to remove nasolabial wrinkles are efficiently reduced in only one month. Spots are reduced and surface pigmentation is homogeneized, for a rejuvenated look.

 

   

   

AkebiSol®: a protective action against the glycation process

Glycation is a spontaneous and non-enzymatic reaction between sugar and collagen that results in the formation of a complex, called Advanced Glycation End-products (AGEs). This complex affects the proteins’ function as it modifies their shapes. Once it is formed, it cannot be undone. In addition, it is also difficult to be broken down by enzymes as the new structure makes it difficult for these enzymes to reach the proteins. Therefore, AGEs cannot be replaced by newly created structures.

In the skin, the glycation process will lead to depletion of the elastin and collagen fibers, responsible for skin elasticity and firmness. This will lead to an unhealthy look and premature signs of aging with the appearance of wrinkles.

To protect the skin against the glycation process, Clariant Active Ingredient has developed a natural active ingredient called AkebiSol. AkebiSol is made from extracts of Akebia quinata fruit, also known as the chocolate vine, a plant native from Korea and Japan. This fruit has a strong anti-glycation activity to prevent the formation of AGEs. It has also an anti-collagenase activity, fighting the breakdown of collagen.

Thanks to AkebiSol, wrinkles will visibly decrease and skin hydration will be improved, for a younger look.    

Dongbaek Oil : the oil with multiple anti-aging properties

Getting older triggers processes that lead to the appearance of aging signs, such as wrinkles. Aging is a normal process. But aging too fast is not. Many inflammatory factors like nitric oxide (NO), prostaglandin E2 (PGE2) and TNF-α are produced leading to the destruction of the natural and major components of skin such as collagen. The accumulation of oxidized proteins makes the skin to look less healthy, and premature signs of aging appear.

To help the skin keeps a fresh and healthy look, Clariant Active Ingredient has developed Dongbaek Oil. This oil is extracted from the seeds of the Camellia japonica, a plant cultivated in Jeju island, a South Korean island rich in endemic plants with superior properties for cosmetics.

Thanks to its unique composition, Dongbaek Oil inhibits the production of NO, PGE2 and TNF-α pro-inflammatory mediators. In addition, it reduces the expression of iNOS and COX-2 genes, responsible for inflammation. Dongbaek Oil has highly effective anti-oxidant and overall anti-aging properties.

 

   

Fuligo®: restructuring the skin from the inside

In the skin, fibroblasts are responsible for the collagen synthesis and building the extracellular matrix. Collagen is the main protein responsible for the skin elasticity and gives connective tissue its ability to hold skin structures in place. Over the time, the renewal of fibroblasts in the epidermis slows down due to a lower activity of the stem cells. This will lead to a decrease in collagen production that will impact the skin quality. Tissues will lose their elasticity and firmness, and wrinkles will appear.

To restructure and redensify the skin, Clariant Active Ingredients has developed Fuligo, a natural active that comes from extracts of a brown seaweed growing wild on Jeju Island in Korea. Sargassum fusiforme is rich in fucoidans, a sulfated polysaccharide. The manufacturing process allows obtaining oligo fucoidans, smaller molecules with higher solubility that can penetrate the skin. The oligo fucoidan induce stem cells and fibroblasts proliferation, and as a consequence leads to collagen production.

Fuligo will efficiently improve skin elasticity, dermal density, and decrease wrinkles to reduce the signs of aging.

   

LotuStem™: skin stem cells revitalization

The skin constantly renews itself throughout life. Stem cells residing in the basal layer of the epidermis ensure the maintenance of skin homeostasis. They multiply into cells that will then differentiate and structure the skin layers. With aging, the division cycles of the stem cells stop and skin renewal will slow down, leading to a poor skin structure and appearance of wrinkles.

To rejuvenate the skin, Clariant Active Ingredients developed LotuStem. This natural ingredient is made of Andrographis paniculata extract, a plant native to India and Sri Lanka. It has been used over centuries for ayurvedic medicine.

LotuStem has demonstrated a high capacity in protecting the stem cells reservoir in order to promote skin differentiation, and so visibly reduce the signs of aging.

 

     

HerbEx™ Korean Ginseng Extract: photoprotector for healthy aging

UV radiation can deeply destroy skin and generates serious damage. In particular, UVB, invisible sunlight in the range from 280 to 320 nm, penetrates the skin's epidermis and is responsible for sunburn. Therefore the skin becomes red, irritated, and keratinocytes cells are less viable. In the long term, UV exposure induces the oxidation of skin components because of ROS (Reactive Oxygen Species) production which degrades essential proteins such as collagen fibers. As a result, MMP-1 (Matrix MetalloProteinase-1), a collagenase enzyme, is stimulated, destroying collagen, and collagen synthesis is reduced over time: skin thickness and density decrease. All these degradations are linked to premature skin aging, wrinkles become deeper and skin texture grainy.

To bring a protection against the sun for a healthy aging, Clariant Active Ingredient developed HerbEx Korean Ginseng Extract. It is obtained from the steam water used in the process to manufacture so-called red ginseng. It targets UV exposure damage by protecting skin components from oxidation and improving their structure, and focuses on signs of aging to refine skin texture. HerbEx Korean Ginseng Extract provides confidence and comfort, helping users age beautifully.

     

HerbCool: coolest thermal aging protector

Skin is exposed daily to a number of damaging factors from its environment. Sun exposure is the main contributor to extrinsic aging, resulting in changes in skin appearance. UV damage is well documented, but the heat coming from a warm sunny day is creating damage as well. Electronic devices present in our daily lives also generate heat that can impact skin quality in time. Indeed, higher skin temperatures contribute significantly to extrinsic skin damage and is now referred to as thermal aging.

To beat the heat shock, Clariant Active Ingredient developed HerbCool, a blend of three plant extracts known for centuries to have beneficial properties on irritated skin: apple mint, thyme and green tea. HerbCool was found to reduce the MMP-1 production linked to heat shock and cause a cooling sensation on skin. It is naturally equipped to help reducing the effects of thermal aging on skin.

   

NLT Adenosphere 2.0: the dermis re-densifier for smoother skin

Over the years, dermis components are less abundant: fibroblasts metabolism becomes sluggish which leads to less collagen production. Decreased synthesis is exacerbated by the accumulation of stress and the stimulation of proteases such as metalloproteinase-1 (MMP-1), which contribute to increased collagen degradation. The result is a break down in dermal scaffolding. Visually, skin sags which leads to an irregular and rough surface, as well as wrinkles.

To support skin against intrinsic and extrinsic aging factors in order to help skin look smoother, Clariant Active Ingredients developed NLT Adenosphere 2.0, a liposome encapsulating adenosine, a molecule recognized for its anti-wrinkle benefits. NLT AdenoSphere 2.0 is a dermis re-densifier, targeting extracellular matrix components improving smoothness, firmness and tonicity. After one month, signs of skin irregularity disappeared and the appearance of crow’s feet wrinkles and nasolabial folds were reduced. Results after two months are outstanding.

A.W.