Anti-aging ingredients

Epseama™: targeting epigenetics through the non long-coding RNA nc886

Gene expression and how they are translated into proteins can be influenced by external factors. This phenomenon is called epigenetics. Some genes are transcripted in non coding RNA (ncRNA), that will not be translated into proteins. Their function is to regulate information flow from DNA to proteins. Recently, it has been shown that the expression of a long non-coding RNA called nc866 decrease with age and can affect skin rejuvenation. 

Clariant Active Ingredient is the first company to have developed an active ingredient for skincare that targets the long-coding RNA nc886, to fight chronoaging and photoaging. Called Epseama, it is made of an extract of Laminaria japonica, a seaweed cultivated in South Korea and commonly used in asian food due to its valuable composition.

Thanks to Epseama, difficult to remove nasolabial wrinkles are efficiently reduced in only one month. Spots are reduced and surface pigmentation is homogeneized, for a rejuvenated look.

AkebiSol™: a protective action against the glycation process

Glycation is a spontaneous and non-enzymatic reaction between sugar and collagen that results in the formation of a complex, called Advanced Glycation End-products (AGEs). This complex affects the proteins’ function as it modifies their shapes. Once it is formed, it cannot be undone. In addition, it is also difficult to be broken down by enzymes as the new structure makes it difficult for these enzymes to reach the proteins. Therefore, AGEs cannot be replaced by newly created structures.

In the skin, the glycation process will lead to depletion of the elastin and collagen fibers, responsible for skin elasticity and firmness. This will lead to an unhealthy look and premature signs of aging with the appearance of wrinkles.

To protect the skin against the glycation process, Clariant Active Ingredient has developed a natural active ingredient called AkebiSol. AkebiSol is made from extracts of Akebia quinata fruit, also known as the chocolate vine, a plant native from Korea and Japan. This fruit has a strong anti-glycation activity to prevent the formation of AGEs. It has also an anti-collagenase activity, fighting the breakdown of collagen.

Thanks to AkebiSol, wrinkles will visibly decrease and skin hydration will be improved, for a younger look.

Dongbaek Oil : the oil with multiple anti-aging properties

Getting older triggers processes that lead to the appearance of aging signs, such as wrinkles. Aging is a normal process. But aging too fast is not. Many inflammatory factors like nitric oxide (NO), prostaglandin E2 (PGE2) and TNF-α are produced leading to the destruction of the natural and major components of skin such as collagen. The accumulation of oxidized proteins makes the skin to look less healthy, and premature signs of aging appear.

To help the skin keeps a fresh and healthy look, Clariant Active Ingredient has developed Dongbaek Oil. This oil is extracted from the seeds of the Camellia japonica, a plant cultivated in Jeju island, a South Korean island rich in endemic plants with superior properties for cosmetics.

Thanks to its unique composition, Dongbaek Oil inhibits the production of NO, PGE2 and TNF-α pro-inflammatory mediators. In addition, it reduces the expression of iNOS and COX-2 genes, responsible for inflammation. Dongbaek Oil has highly effective anti-oxidant and overall anti-aging properties.

Fuligo : restructuring the skin from the inside

In the skin, fibroblasts are responsible for the collagen synthesis and building the extracellular matrix. Collagen is the main protein responsible for the skin elasticity and gives connective tissue its ability to hold skin structures in place. Over the time, the renewal of fibroblasts in the epidermis slows down due to a lower activity of the stem cells. This will lead to a decrease in collagen production that will impact the skin quality. Tissues will lose their elasticity and firmness, and wrinkles will appear.

To restructure and redensify the skin, Clariant Active Ingredients has developed Fuligo, a natural active that comes from extracts of a brown seaweed growing wild on Jeju Island in Korea. Sargassum fusiforme is rich in fucoidans, a sulfated polysaccharide. The manufacturing process allows obtaining oligo fucoidans, smaller molecules with higher solubility that can penetrate the skin. The oligo fucoidan induce stem cells and fibroblasts proliferation, and as a consequence leads to collagen production.

Fuligo will efficiently improve skin elasticity, dermal density, and decrease wrinkles to reduce the signs of aging.

LotuStem: skin stem cells revitalization

The skin constantly renews itself throughout life. Stem cells residing in the basal layer of the epidermis ensure the maintenance of skin homeostasis. They multiply into cells that will then differentiate and structure the skin layers. With aging, the division cycles of the stem cells stop and skin renewal will slow down, leading to a poor skin structure and appearance of wrinkles.

To rejuvenate the skin, Clariant Active Ingredients developed LotuStem. This natural ingredient is made of Andrographis paniculata extract, a plant native to India and Sri Lanka. It has been used over centuries for ayurvedic medicine.

LotuStem has demonstrated a high capacity in protecting the stem cells reservoir in order to promote skin differentiation, and so visibly reduce the signs of aging.