The holistic skin rejuvenator

Edition Date :
May 18, 2021

Epseama is the first active ingredient in the market that targets a long non-coding RNA to fight the three main causes of aging: photoaging, chronoaging, and inflammaging. It boosts the expression of nc886, a long non-coding RNA which expression decreases dramatically with age in women after 40-years-old.

By boosting nc886, Epseama inhibits the production of MMP-9, a collagenase that degrades collagen IV, and increases the production of collagen IV, VII and XVII that are key components of the dermis-epidermis junction. As a consequence, Epseama helps the skin recover its resistance and elasticity.

Epseama is made from an extract of Laminaria japonica, a brown seaweed known as the "superfood of the sea" thanks to its composition rich in vitamins and minerals. This algae is farmed on the shore of South Korean island through sustainable and responsible aquaculture practices.

Epseama has won the silver prize of the BSB Innovation Awards in the category "Active Ingredients" at in-cosmetics 2019 - Learn more www.clariant.com/epseama.

To discover our other active ingredients, visit our homepage Clariant Active Ingredients.


Epseama manages to reduce difficult-to-remove nasolabial wrinkles by 19% in volume and 10% in roughness in only one month (clinical trial on 19 women over 50 years-old).

It also reduces pigmented spots and improves skin hydration.

Catherine Centro
Catherine Centro
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Chemical Name
  • Glycerin, Water, Laminaria, Japonica Extract
Product Function
  • Active Ingredient
Chemical Type
  • Botanical Derivatives
  • Cream, Lotion
  • Colour Cosmetic
Performance Claims
  • Anti-aging
  • Boosts extracellular matrix
  • Reduces age spots
  • Protects from photoaging
  • Protects from chronoaging

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Epseama is an active ingredient that can be used in various skincare and cosmetic products, such as:

- Avant-garde anti-aging cares

- Intensive serums for facial rejuvenation

- Resurfacing products

- Rejuvenation night creams

Technical data
INCI Name: Glycerin, Water, Laminaria Japonica Extract

Use level: 1-5%

Appearance: yellow liquid

Origin: Extract of Laminaria japonica from South Korea

Certification: China IECIC listed
Epseama can be associated with Eosidin for a broader anti-inflammaging effect, or with HerbEx Korean Ginseng Extract for a stronger anti-photoaging effect.
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Catherine Centro
Catherine Centro
Contact Person