The senescence preventer for healthy aging

Edition Date :
April 19, 2021

Celyscence is an extract of the seedless milk thistle flower (Sylibum marianum) that prevents the accumulation of senescent cells (also called "zombie cells") in the skin thanks to three different activities:

1- Celyscence prevents cells from becoming senescent

2- Celyscence activates the apoptosis process in senescent cells to eliminate them (senolytic effect)

3- Celyscence turns back the phenotype of senescent cells into younger cells, thus preventing them from producing SASPs, some deleterious molecules that cause senescence in surrounding cells (senomorphic effect)

Thanks to this triple mode of action, Celyscence restores skin healthiness, which was demonstrated on clinical studies: on the chest, wrinkles are decrease and luminosity is increased, to help women feel more confident in their femininity. On the face, melanin content was reduced to increase skin brightness.

To discover our other active ingredients, visit our homepage Clariant Active Ingredients.


After 56 days, décolleté hydration is increased by 14% and brightness by 3.2%. After only 28 days, the neck is visibly firmer, smoother, and facial contours are remodeled.

After 14 days, melanin content on the face is decreased by 5.4%.

Catherine Centro
Catherine Centro
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Celyscence is an active ingredient that can be used in various skincare and cosmetic products, such as:

  • Anti-aging creams
  • Neck firming cream
  • Décolleté complexion boosters
Technical data

INCI Name: Glycerin, Water, Silybum Marianum Extract

Use level: 1-5%

Appearance: yellow to slightly brown liquid

Compliance: China IECIC listed, Plant origin

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Catherine Centro
Catherine Centro
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