Polyglykol 10000 S*

PEG are non-toxic and physiologically safe so no special safety precautions need to be taken when handling them. For many applications, particularly in pharmaceuticals, cosmetics and foodstuffs packaging, the physiological safety of PEG is important. When administered orally and cutaneously they are to be rated as non-toxic. The vapour pressure of PEG is so low that inhalation of relevant amounts is impossible. Because of their good physiological tolerability PEG were first included in the US pharmacopoeia already in 1950. Since then they have been listed in numerous pharmacopoeias. The tolerability of PEG in animals improves as the degree of polymerization rises. PEG have no toxic or irritant effect on the skin. Because of low toxicity it was not possible to establish an exact LD50 resulting from skin penetration.

Ecological Data
The behavior of PEG in effluent is a matter of crucial importance, e.g. in their industrial use in the textile sector and in metal processing. The rate of biodegradation of PEG decreases with increasing molar mass. PEG up to molar mass 1500 are regarded as readily biodegradable (Zahn-Wellens test). The microbiological degradation of other substances is not inhibited by the presence of PEG. The toxic inhibition limit for bacteria in the fermentation tube test is 5000 mg/l. Investigations within our own labs have shown that even in concentrations of 10000 mg/kg (1%) polyethylene glycols have no adverse effect on fish (crucian carp). Polyethylene glycols in concentration up to 10000 mg/l exhibit no harmful effect of any kind towards daphnia and protozoa. The German water hazard class is WGK 1.

Waste Disposal
Any PEG to be disposed of waste can be taken, in accordance with the local regulations, to a special waste incineration plant. None of PEG, in concentrations up to 10,000 mg/l water, demonstrates an acute harmful effect on fish or bacteria.

Flakes

Excipient, IPEC GMP; Kosher certificate

Polyglykol 10000 S is suitable as readily water-soluble carrier in the moulding of detergent blocks. It is also recommended as a binder in bath salts, denture cleaners etc when they are pressed into tablet form.

Polyglykol 10000 S acts as a viscosifier and moisturizer in hair conditioner and hair styling products.

Solvent, Binder

Germany

INCI-PEG	220
Hazen Colour 25% a.i.in water	max. 30
Molecular Mass [g/mol]	9000-11250
OH value [mg koh/g]	10-12
Solidification point [°C]	55-62
Viscosity at 20°C [mPa·s]	50% 550-750
Viscosity at 98.8°C=270°F [mm²/s]	-
PH 5% aqueous solution	5.0-7.5
Water content [% M/M]	max. 1
Density at 20°C [g/cm³]	Solidified melt 1.20
Vapour pressure at 20°C [hPa]	< 0.001
Solubility in Water at 20°C [% M/M]	53

PEG 10000 S is stable for 6 months when stored in the original sealed containers in a cool, dry place.

Furthermore the containers should not be exposed to direct sun light. Ambient temperatures for long term storage are preferably between 10°C and 25°C and between 0°C and 30°C as maximum. Storage at higher temperatures is possible only for a short time and should be kept below the solidification point of the products.

The most suitable material for storage tanks is stainless steel, pure aluminium, rubber-or polyethylene lined containers and storage tanks made from glass-fibre-reinforced polyester (GRP). The tank should be ventilated by means of a silica gel dryer. Conventional steel tanks are of limited suitability because after prolonged storage the product may become discoloured owing to traces of iron.