We are in decades of pharmaceutical excellence
Clariant delivers pharmaceutical-grade PEGs with unmatched purity and consistency through 30+ years of manufacturing expertise. Our ICH Q7-compliant production facilities utilize dedicated reactors and undergo rigorous GMP audits, ensuring APIs that meet Ph.Eur., USP-NF, and JP requirements across multiple physical forms.
IFAs de PEGs para aliviar a constipação em formulações de laxantes
PEG APIs to bring constipation relief in Laxative formulations
Clariant's PEG-based laxative APIs work through an osmotic mechanism that retains water in the intestine, providing gentle, effective constipation relief. Our products offer significant advantages over alternative treatments: minimal absorption in the digestive tract, absence of side effects compared to lactulose, and suitability for long-term use—even in children as young as two years.
Key Advantages of Clariant PEG Laxative APIs:
- Osmotic mechanism: Retains water in intestine for gentle, natural bowel movement
- Minimal systemic absorption: PEG not absorbed in the digestive tract
- No dependency: Suitable for long-term use unlike stimulant laxatives
- Pediatric use: Clinically proven safe for children as young as 2 years
- Fewer side effects: Better tolerated than lactulose (no bloating, cramping)
- 30+ years expertise: Clariant's dedicated pharmaceutical PEG manufacturing
- Full compliance: ICH Q7 GMP, Ph.Eur., USP-NF, JP monographs
IFA para PEG como umectante para alívio imediato em formulações oftálmicas
PEG API as GMP-compliant demulcent for ophthalmic solutions
O Polyglykol 400 J é um produto líquido da classe de IFAs para PEGs, produzido sob condições Q7 estabelecidas pela ICH e certificado como boa prática de manufatura pelas autoridades alemãs. É especificado de acordo com os requisitos das diretrizes e monografias internacionais da ICH. Com sua especificação microbiológica adicional (inclusive para endotoxinas), é possível atender a requisitos especiais de formulação.
PEG Laxative APIs
<h3>What PEG molecular weight is used in osmotic laxatives?</h3>
<p>PEG 3350 and PEG 4000 are the standard molecular weights used in osmotic laxative formulations. Clariant supplies both grades under the Polyglykol brand, manufactured in ICH Q7-compliant facilities with full pharmacopoeia documentation (Ph.Eur., USP-NF, JP).</p>
<h3>How do PEG-based osmotic laxatives work?</h3>
<p>PEG laxatives work through an osmotic mechanism: the PEG molecules retain water in the intestinal lumen, softening stool and stimulating natural bowel movements. Unlike stimulant laxatives, PEG laxatives do not cause dependency and are suitable for long-term use.</p>
<h3>Are PEG laxatives safe for children?</h3>
<p>Yes. PEG-based laxatives have been clinically proven safe for children as young as two years. The active ingredient shows minimal absorption in the digestive tract, making it well-tolerated with an absence of the side effects commonly associated with lactulose.</p>
<h3>What GMP certifications does Clariant hold for PEG API manufacturing?</h3>
<p>Clariant manufactures PEG APIs in dedicated reactors under ICH Q7-compliant GMP conditions. Facilities undergo rigorous audits and products meet Ph.Eur., USP-NF, and JP monograph requirements. Clariant has 30+ years of pharmaceutical PEG manufacturing expertise.</p>
<h3>What is Polyglykol 400 J used for in ophthalmic applications?</h3>
<p>Polyglykol 400 J is a pharmaceutical-grade PEG 400 used as a demulcent API in eye drop formulations. It forms a protective film over the ocular surface, mimicking natural mucins to relieve dry eye symptoms. The product meets stringent microbiological and endotoxin specifications required for ophthalmic use.</p>
<h3>What is the difference between a PEG API and a PEG excipient?</h3>
<p>A PEG API (Active Pharmaceutical Ingredient) is the therapeutically active component – e.g., PEG 3350 as an osmotic laxative. A PEG excipient is a functional additive that supports drug delivery (e.g., as a binder, solubilizer, or coating agent) without therapeutic effect. Clariant supplies both: PEG APIs (this page) and PEG excipients (VitiPure, Polyglykol ranges).</p>
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