Counterions enhance drug solubility by forming dissociable salts that improve bioavailability. Clariant's pharmaceutical-grade Meglumine serves as an effective counterion for anionic APIs (pKa < 6), offering versatile functionality beyond its traditional use in contrast media. As both a salt-forming agent and functional excipient, Meglumine enhances API solubility and stability while providing precise pH adjustment for optimal pharmaceutical formulations.