In 2017, the Nobel Prize in Physiology or Medicine awarded discoveries on the molecular mechanisms controlling circadian rhythm. This global rhythm is regulated by the brain, but the skin, specifically each cell, possesses its own internal clock governing major biological responses following this 24-hour rhythm. Four genes are implicated in circadian rhythm: B-mal, Per, Cry and Clock. But their expression can be altered by external factors such as stress, jet lag, or exposure to blue light. A dysregulated circadian rhythm affects the skin well-being, that shows signs of fatigue. B-Circadin has demonstrated its efficacy to resynchronize the rhythm of Bmal-1, Per and Cry circadian genes on a unique model of synchronized skin exposed to blue light as a stress factor to deregulate its circadian rhythm. As a consequence, it also demonstrated its efficiency in regulating key biological functions such as aquaporin 3 and Nrf2 pathway, known to follow a circadian rhythm. Thanks to B-Circadin, the skin well-being is restored. B-Circadin also showed a protective action against blue light induced oxidative stress on skin cells. It is extracted from Lespedeza capitata, a medicinal plant originated from South Korea. To discover our other active ingredients, visit our homepage Clariant Active Ingredients.